Activate your "Skinny" and anti-aging gene!
What is SIRT1?
SIRT1 is a gene found in humans and other mammals that helps to promote survival by protecting cells during times when food (and therefore energy) is scarce. Scientists have discovered similar genes in almost all species, including Sir2 in yeast, worms, and fruit flies. SIRT1 acts as a "rescue gene," repairing the damage done by free radicals and preventing cells from dying prematurely. The gene also causes mitochondria, the power plants of cells, to produce energy at higher levels that are typically associated with younger cells. As a result, SIRT1 is believed to be a principal regulator of lifespan.
The Benefits of SIRT1
The SIRT1 gene, or "skinny gene," assists with weight loss by inhibiting fat storage and increasing fat metabolism. By causing the body to store fewer fat cells, SIRT1 can also slow the aging process by reducing the risk of age-related diseases and health threats, including heart attack and stroke, diabetes, arthritis, and osteoporosis. These conditions have all been linked to an excess amount of fat cells in the body. In addition, SIRT1 can reduce markers of inflammation and oxidative stress, two other primary causes of aging. Studies show that individuals who live to be 100 years old have lower levels of oxidative stress, meaning fewer free radical cells, than those who live to be 70. Oxidative stress is also thought to be a more reliable indicator of heart disease than cholesterol levels or other factors. In my treatment of rheumatoid arthritis and asthma patients, I have seen that restricting calories on alternate days can raise SIRT1 levels and reduce symptoms associated with inflammation of the joints or bronchial tract.
How is the gene activated?
SIRT1 is activated by calorie restriction or by the compound in red wine known as resveratrol. The body's response to calorie restriction is an example of "hormesis," in which a normally dangerous stressor can actually be beneficial in small amounts. Although an animal will die if it starves, moderate calorie restriction can actually increase its chances of survival by raising levels of SIRT1.
